CWI Glutathione emphasis
Glutathione is the single most important antioxidant in the human body. Not only does it function to quench free radicals, but it is a naturally occurring chelating agent in the human body to help it rid itself of toxins. Glutathione binds with heavy metals in the body, rendering them inactive and unable to harm cells. Once bound with glutathione, the metals and other wastes are more readily expelled from the body – drastically decreasing the damage they do and increasing the body’s ability to absorb the essential metals necessary for proper brain and body function.
We can actually measure this antioxidant in the human body with a number of different tests: Spectracell Micronutrient Assay and functional testing using the Organic Acid Test from Great Plains Diagnostic Lab, or the Oxidative Stress test from Genova Diagnostics. This later one is probably the best of the lot for direct measurement of intracellular glutathione.
- The same problems and symptoms associated with antioxidant deficit are also associated with low glutathione. More specific studies are cited in some cases:
- In addition, in terms of attending to the general medical needs of our patients, we also key in on this area because of the correlation of poor glutathione status with
- Cancer riskincluding
- Dermatological conditions
- Eye health
- Gastrointestinal/”gut” diseases and problems:
- Inflammation (in general)
- Neurodegenerative diseases
- A clinical trial of glutathione supplementation in autism spectrum disorders. Kern JK, et al. Med Sci Monit. 2011.
- Bio-marker guided interventions of clinically relevant conditions associated with autism spectrum disorders and ADHD. Bradstreet, JJ et al. Altern Med Rev. April 2010
- Glutathione: A novel treatment target in psychiatry. Berk, M et al. Trends Pharmacol. July 2008.
- Glutathione dysregulation and the etiology and progression of human diseases. Ballatori, N et al. Biol Chem. 2009 (complete article)
- Glutathione in health and disease. Lomaestro, B et al. Annals of Pharmacotherapy 1995 (complete article)
- Glutathione is a key player in metal-induced oxidative stress defenses. Jozefczak M, et al. Int J Mol Sci. 2012.
- Glutathione: overview of its protective roles, measurement, and biosynthesis. Forman, HJ et al. Mol Aspets Med. 2009;30(1-2):1-12. (Complete review article)
- Glutathione pathway gene variation and risk of autism spectrum disorders. Bower, K et al. J. Neurodev Disord. June 2011.
- Glutathione: systemic protectant against oxidative and free radical damage. Kidd, PM. Alt Med Rev 1997.
- Oxidative stress biomarkers in mitochondrial myopathies, basally and after cysteine donor supplementation. Mancuso M et all. J Neurol May 2010.
- Prodrugs of L-cysteine as protective agents against acetaminophen-induced hepatotoxicity. Roberts, JC, Nagasawa, HT et al. J. Med Chem Oct. 1987. (This is the seminal article on the discovery and then subsequent development of Riboceine.)
- The Importance of glutathione in human disease. Townsend DM et al. Biomed Pharmacother. May-June 2003.
- The severity of autism is associated with toxic metal body burden and red blood cell glutathione levels. Adams, JB et al. J. Toxicol. 2009.Here are some specific references to get you started: